Calcineurin Inhibitors Atopic Dermatitis Treatments

calcineurin inhibitors atopic dermatitis treatments

Atopic dermatitis is an inflammatory disease of the skin that affects infants and children. It can affect adults, but it adults suffer from atopic dermatitis are typically those who developed the condition in childhood. For years, the only available topical treatment was the use of over-the-counter, low-dose steroids or corticosteroids that are only available with a prescription. This all changed almost 20 years ago.

Calcineurin Inhibitors for Atopic Dermatitis Treatment

In 2000, the FDA gave a topical formulation of two calcineurin inhibitors the nod of approval for its use in patients 2 and under. Other treatments were ineffective and became contradictory for such small children. These topical treatments became quickly popular among pediatricians and dermatologists alike. This was especially due to the long-term side effects that come with long-term corticosteroid use, especially in children. However, with these new TCIs, there has been an increase in lymphoma after use. Back in 2006, there was a box-warning placed on this medication, cautioning physicians and patients.

There is currently no cure for atopic dermatitis. Most times, it is caused by an abnormal reaction of some kind within the body. Patients are recommended to evaluate the foods they consume to try to eliminate some that may be impacting their immune system function. Foods that are highly acidic like oranges and tomatoes are usually the first recommendation. Removing them for 30 days and then re-introducing them into a diet can show if a patient reacts to the foods or not.

Gluten is often another food culprit for AD and eczema flares.

If home remedies like emollients and low-dose steroids don’t work, contact your pediatrician to see if you can try topical calcineurin inhibitors. Like most medicines, there are always side effects unless it is an all-natural remedy. However, most cases are too severe for natural treatment methods. Use creams and ointments that have no preservatives or perfumes as they can further irritate the skin. Finally, always consult your physician if you decide to try a treatment option you have not tried before.

Featured Image: genious2000de via DepositPhotos

Posted on May 22, 2023